Evaluation of ve in a Rat Glioma Model with DCE-MRI and Quantitative SPECT
نویسندگان
چکیده
Introduction Dynamic contrast enhanced MRI (DCE-MRI) is used to characterize perfusion and extracellular volume in tumors through the tracer kinetic modeling of MRI contrast agents (typically Gd-DTPA). However, the parametric estimates resultant of DCE-MRI may be influenced by several confounding factors, including inter-compartmental water exchange [1]. In contrast to MRI contrast agents, radiotracer imaging with SPECT uses direct measures of tracer activity and is, therefore, insensitive to water dynamics. Here we compare extracellular volume, ve, in a C6 glioma model in rat brain as measured by DCE-MRI and dual-isotope SPECT.
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